RAD 180 - Introduction to Radiation Biology

1. Verbally provide a brief synopsis of the history of radiation biology, including a few epidemiologic case studies that have contributed to our knowledge of radiobiology.
2. Discuss and mathematically convert conventional units of radiation to their system international counterparts.
3. State the Laws of Bergonie and Tribondeau (biologic factors) and discuss the physical factors affecting cell and organ radiosensitivity.
4. Identify cellular anatomy and specific cellular organelles as it related to cellular function and radiobiologic damage.
5. Discuss local tissue effects as it relates to the eyes and skin.

1. Discuss the conventional and SI fundamental units of radiation measurement and mathematically calculate their conversion from one to another.
2. Briefly identify the timeline for the history of Radiobiology from 1895 to present and discuss a few epidemiologic studies that have contributed to our understanding of radiobiology.
3. List the three essential duties of a radiographer as it relates to radioprotection.
4. Describe the differences in mitosis and meiosis for somatic and genetic cell duplication.
5. Identify which subphase of mitosis and stage of interphase is the most radiosensitive for somatic cells.
6. State the Laws of Bergonie and Tribondeau (biologic factors) as it relates to cell radiosensitivity.
7. Briefly describe the physical factors that influence cell, tissue, and organ radiosensitivity.
8. Identify cellular organelles present in the cytoplasm and discuss their function and relative radiosensitivites and/ or resistance.
9. Explain the three basic categories of radiation hazards for whole body dose.
10. List the function and percentages of each critical molecule in the body.
11. Describe the difference in nitrogenous base pairs for RNA and DNA.
12. State the protracted cataractogenesis threshold dose experienced by cyclotron physicists.
13. State the SED and SED50 for the general population in SI units.

1. Introduction, History and Categories of Biologic Effects
2. Conventional and System International Radiation Units
3. Cellular Anatomy;/Organelle Function
4. Radiosensitive Phases of Mitosis and Meiosis
5. Law of Bergonie and Tribondeau (Biological and Physical Factors)
6. Local Tissue Effects (Cytogenetic Damage)
7. Radiation Induced Malignancies/Life Span Shortening